Providing practical, visually oriented guidance on the benefits of botulinum toxin in a wide variety of disorders, some new and unexpected, this new edition of Manual of Botulinum Toxin Therapy is fully updated in scope and detail. Chapters discuss the pathophysiology of each condition, summarizing the rationale for botulinum toxin, and describing the injection approach. Clear illustrations of the injection sites are included, using a 'clinician's eye' perspective, which allows physicians to readily identify anatomical landmarks and approach angles for injection. Dosing tables for available toxin formulations are included. The Manual covers cosmetic treatment of the upper and lower face, as well as aesthetic smile correction. Extensive guidance on how to use ultrasound and how cadaveric dissections can assist localization and targeting of injections is provided. Designed for teaching and bedside guidance, the Manual is useful to a diverse range of clinicians looking to use botulinum toxin in their practice.

One of Britain’s most important and influential painters, Sir Joshua Reynolds (1723 size=1 color=black>–1792) is justly celebrated for his dynamic portraiture, his poignant ‘fancy pictures’, his ambitious history paintings and his role as the first President of Britain’s Royal Academy. Published to accompany a major exhibition at the Wallace Collection, London (12 March size=1 color=black>–7 June 2015), and the result of the four-year research project, this catalogue focuses on Reynolds's innovative, often highly experimental approaches to the practice and materials of painting. It investigates his radical manipulation of pigments, oils, glazes and varnishes, and traces his experiments with colour, tone and handling. It reveals his continual temptation to rework and revise his pictures, illuminates his highly creative responses to the new exhibition culture of his day and explores his continual adaptations of the art of the Old Masters. In doing so, it encourages us to look at the work of this famous eighteenth-century British artist in a new and often surprising light. Technical analysis of some of Reynolds's most important paintings will be revelatory, and close-up photography and detailed examination of a range of pictures size=1 color=black>– at the centre of which are the Wallace Collection’s own outstanding collection of works by the artist size=1 color=black>– will shed light on the fascinating and ongoing process of experimentation that spanned Reynolds’s entire career. The book situates Reynolds’s practice of experimentation, of both technique and of subject, in relation to that conducted at leading societies of science and learning at the time, and specifically to Josiah Wedgwood, one of Enlightenment Britain’s greatest experimentalists in the arts. Finally, it demonstrates how Reynolds’s innovations as a painter were often the product of collaboration size=1 color=black>– in part, with his assistants and his students, but, more importantly, with his patrons and subjects, with whom he continually explored the possibilities of gesture, expression, performance and role-play.

From The Land Before Time to Jurassic Park, images of fantastically large, long-necked, plant-eating dinosaurs have captured our imaginations. These are the sauropods: centerpieces of museums and gentle giants of the distant past. Imagine what it must have been like to crest a hill and see in the valley below not just one sauropod, but an entire herd, feeding its way across the landscape. The most massive land animals ever to have lived, sauropods roamed widely across the continents through most of the "Age of Dinosaurs" from about 220 to 65 million years ago. They reached incredible sizes, giving rise to the question: Why were they so big? Early guesses suggested that they gained protection from predators by virtue of their size, which also allowed them to reach the tops of trees in order to eat leaves and conifer needles. More recent hypotheses hold that they needed a long and complicated digestive tract due to their consumption of low-nutrient food sources: size was an offshoot of that need. Whatever the explanation, there is little doubt that natural selection produced something extraordinary when the Sauropoda diversified into a wide variety of species. This book combines majestic artwork and the best of paleontological research to resurrect the lives of sauropods. The Sauropod Dinosaurs shows how these amazing creatures raised and defended their young, traveled in groups, and interacted with the rich diversity of Mesozoic plants and animals. Beautiful enough to sit on the coffee table, the book also serves as the best reference available on these bygone giants. Anyone with a passion for dinosaurs or prehistoric life will cherish this once-in-a-generation masterpiece. The book includes the following features:* Over 200 full-color illustrations* More than 100 color photographs from museums, field sites, and collections around the world* Thoughtfully placed drawings and charts* Clearly written text reviewed by major sauropod researchers* Descriptions of the latest sauropod concepts and discoveries* A field guide to major groups of sauropods* Detailed skeletal reconstructions and anatomical restorations* A comprehensive glossary

Offering a state-of-the-art, authoritative summary of the most relevant scientific and clinical advances in the field, Principles and Practice of Movement Disorders provides the expert guidance you need to diagnose and manage the full range of these challenging conditions. Superb summary tables, a large video library, and a new, easy-to-navigate format help you find information quickly and apply it in your practice. Based on the authors' popular Aspen Course of Movement Disorders in conjunction with the International Parkinson and Movement Disorder Society, this 3rd Edition is an indispensable resource for movement disorder specialists, general neurologists, and neurology residents. Explores all facets of movement disorders, including the latest rating scales for clinical research, neurochemistry, clinical pharmacology, genetics, clinical trials, and experimental therapeutics. Provides the essential information you need for a clinical approach to diagnosis and management, with minimal emphasis on basic science. Reflects recent advances in areas such as the genetics of Parkinsonian and other movement disorders, diagnostic brain imaging, new surgical approaches to patients with movement disorders, and new treatment guidelines for conditions such as restless legs syndrome. Features a reader-friendly, full-color format, with plentiful diagrams, photographs, and tables. Includes access to several hundred updated, professional-quality video clips that illustrate the manifestations of all the movement disorders in the book along with their differential diagnoses. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Big cats such as lions, tigers, leopards, and jaguars fascinate us like few other creatures. They are enduring symbols of natural majesty and power. Yet despite the magnetic appeal of the big cats, their origins and evolutionary history remain poorly understood-and human activity threatens to put an end to the big cats' glory. On the Prowl is a fully illustrated and approachable guide to the evolution of the big cats and what it portends for their conservation today. Mark Hallett and John M. Harris trace the origins of these iconic carnivores, venturing down the evolutionary pathways that produced the diversity of big cat species that have walked the earth. They place the evolution and paleobiology of these species in the context of ancient ecosystems and climates, explaining what made big cats such efficient predators and analyzing their competition with other animals. Hallett and Harris pay close attention to human impact, from the evidence of cave paintings and analysis of ancient extinctions up to present-day crises. Their engaging and carefully documented account is brought to life through Hallett's detailed, vivid illustrations, based on the most recent research by leading paleontologists. Offering a fresh look at the rise of these majestic animals, On the Prowl also makes a powerful case for renewed efforts to protect big cats and their habitats before it is too late.

The second edition of The Neurologic Examination looks at how to conduct a clinical neurological examination through a pathophysiological approach to the nervous system. This new edition is brought up to date with new data on genetic and immunological disorders and a significant expansion of illustrations of skin manifestations of neurologic disorders. The book provides in-depth instructions for clinicians with a logical order of history and the different parts of the examination. Organized by the functional anatomy of the nervous system, the book provides a bridge from basic science to symptoms and signs of many common and rare neurologic disorders, which will help in making diagnoses. The authors look at how to carry out an examination in different circumstances, from outpatients to patients in respiratory distress, with stroke and epilepsy, and various states of consciousness including coma. Laboratory testing is recommended when appropriate, but the main emphasis is on history and physical examination. The book contains over a hundred discussion boxes with details about neurologic disorders and history. While mainly directed to students and residents learning how to do a neurologic examination, it will still be useful even for more experienced clinicians.

Kornhuber and Deecke first recorded and reported the Bereitschaftspotential in 1964. The aim of this book is to bring together in a single volume some of the important research on the Bereitschaftspotential and other movement-related cortical potentials and to highlight and address some of the pertinent questions relating to the Bereitschaftspotential and to identify the key issues for future investigation in this field. This book represents a unique compilation of information about the Bereitschaftspotential and related cortical potentials and techniques for measuring preparatory processes in the brain. The book will be of interest to motor physiologists, psychologists and neurologists working in clinical or research laboratories.

Kornhuber and Deecke first recorded and reported the Bereitschaftspotential in 1964. The aim of this book is to bring together in a single volume some of the important research on the Bereitschaftspotential and other movement-related cortical potentials and to highlight and address some of the pertinent questions relating to the Bereitschaftspotential and to identify the key issues for future investigation in this field.

This book represents a unique compilation of information about the Bereitschaftspotential and related cortical potentials and techniques for measuring preparatory processes in the brain. The book will be of interest to motor physiologists, psychologists and neurologists working in clinical or research laboratories.

The neurologic subspecialty of Movement Disorders is complicated with many different entities, making the differential diagnosis difficult. One of the most important aspects of these different entities is their visual appearance. Still photographs do not give sufficient information, but videos like the ones included in this volume can provide dimension, context, and critical information. The variety of visual appearances is wide and seeing many videos is necessary to develop skill in making a diagnosis. Involuntary movements are even more complicated and the adage "seeing is believing" has never been more true. Despite this, few books include videos portraying involuntary movements. Involuntary Movements: Classification and Video Atlas pairs descriptions of the clinical features of various involuntary movements with video depictions of the involuntary movements in action. In a unique approach, this book considers two aspects of the diagnosis of involuntary movements: the phenomenology - as depicted in approximately 200 video supplements - and the etiology. The book also discusses the current consensus on the classification, pathophysiology, and treatment of each involuntary movement.

The field of brain stimulation is expanding rapidly, with techniques such as DBS, TMS, and tDCS moving from the research community into clinical diagnosis and treatment. Clinical applications include treating disorders such as Parkinson's disease, dystonia, and even depression.

The chapters of "Brain Stimulation" are written by leading international researchers and clinical specialists include coverage of techniques, modes of action and applications in physiology and therapeutics. The combination of research and clinical coverage will be of interest to neurologists, neurosurgeons, psychiatrists, neuroscientists, and health care workers.
A comprehensive introduction and overview of deep brain stimulation (DBS)Coverage of DBS, transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS)Details the basic science and research utility of DBS and clinical application

Conversion is very common but often misdiagnosed; even when diagnosed, treatment is difficult. It is critical for physicians to have the necessary knowledge to manage these patients in the most effective way. This volume gives all of the available, up-to-date information on when to think about conversion in movement disorders, how to make a diagnosis, how to use the laboratory to support a clinical diagnosis and how to develop a therapeutic plan. Written by experts in neurology, psychiatry, psychology, neuroimaging, neurophysiology and genetics, this book covers psychogenic movement disorders and other conversion disorders from all of the most relevant clinical angles. An accompanying CD-ROM with a video library featuring over 100 real-life examples of movement disorders will aid diagnosis. Neurologists and psychiatrists, as well as others interested in brain pathophysiology at the boundary of neurology and psychiatry, will find this a useful aid to both clinical practice and research.

Functional Neurologic Disorders, the latest volume in the Handbook of Clinical Neurology series, summarizes state-of-the-art research findings and clinical practice on this class of disorders at the interface between neurology and psychiatry. This 51-chapter volume offers an historical introduction, chapters on epidemiology and pathophysiolology, a large section on the clinical features of different type of functional neurologic symptoms and disorders (including functional movement disorders, non-epileptic seizures, dizziness, vision, hearing, speech and cognitive symptoms), and then concluding with approaches to therapy. This group of internationally acclaimed experts in neurology, psychiatry, and neuroscience represent a broad spectrum of areas of expertise, chosen for their ability to write clearly and concisely with an eye toward a clinical audience. This HCN volume sets a new landmark standard for a comprehensive, multi-authored work dealing with functional neurologic disorders (also described as psychogenic, dissociative or conversion disorders).

The book is the first comprehensive description of the clinical neurophysiology of movement disorders. While movement disorders is a rapidly growing field, and clinical neurophysiology can be helpful, only single articles or selective or brief reviews have so far appeared. The book, as all books in the handbook series, is arranged with a set of detailed chapters on technique and a separate set of chapters on disorders. An international team of authors has been selected to provide the most expert descriptions.

Seismosaurus: The Earth Shaker is a richly illustrated telling of the trials and triumphs of the discovery and excavation of Seismosaurus hallorum, the longest dinosaur yet known - and possibly the largest land animal ever to have lived. This is the first book to explain clearly the science used by paleontologists and the new cutting-edge techniques that led to Seismosaurus's discovery. David Gillette's first-person account of the project answers the most frequently asked questions about Seismosaurus: How was it discovered? How do we know it is a new species? How was it named? And more intriguing still, how did it die? His chronicle also examines the sauropods in general - the giant dinosaurs that with Seismosaurus include Apatosaurus (Brontosaurus), Brachiosaurus, and Diplodocus. This lively tale of discovery is woven with anecdotes and descriptions of the details of the excavation, which began with small jackhammers and later incorporated such sophisticated machinery as ground-penetrating radar that "looks" for fossils underground with radio waves. The story moves from the excavation site in 1985 to current advances in research and then back to the prehistoric age as Gillette, in adventure-narrative style, describes the habitat, habits, and characteristics of the sauropod, right down to Seismosaurus's gastroliths - stomach stones that helped in digestion. Part catalogue of the workings of paleontological science in the 1990s, the book also illustrates the exciting collaboration between David Gillette and the chemists and physicists who helped to reconstruct Seismosaurus and its life. Excavation of the Seismosaurus skeleton was completed in the fall of 1993. Some bones are already ondisplay at the New Mexico Museum of Natural History. Meanwhile, Mark Hallett, a consultant on Steven Spielberg's Jurassic Park, brings Seismosaurus to life in more than eighty marvelous color and black-and-white illustrations. Seismosaurus: The Earth Shaker is a delight!

William Hogarth (1697-1764) is certainly one of the most versatile, innovative and celebrated of all British artists. He lived at a time when Britain was emerging as an increasingly urbanized, commercialized and aggressively imperial power. Like many other artists, he exploited and benefited from these changes in British society. Among his contemporaries, it was Hogarth who commented most brilliantly on society - both positively and negatively. His work celebrates the benefits of commerce, politeness and patriotism while simultaneously focusing on the corruption, hypocrisy and prejudice they brought in their wake. In paint and in print we are shown the two contrasting sides of modernity. This book explores and explains the dramatic duality within Hogarth's work, and in doing so gives us a greater sense of the contradictions and complexities that existed within eighteenth-century British society.

The first extended study of Frank Auerbach's remarkable portrait drawings reveals their complexity and ambition as works of graphic art This book offers an original approach to one of Britain's leading artists: Frank Auerbach (b. 1931). It looks in detail at his portrait drawings, which Auerbach has been making since the 1950s, and which he has always considered important, freestanding works of art. By turns eerie, shocking, enigmatic, and hauntingly tender, they demand fresh interpretation and investigation. Reproducing more than 130 examples of these portraits, some for the first time, and featuring new essays by curators, scholars, and critics, this book provides an unprecedented opportunity to explore and reassess these striking and sometimes unsettling works of graphic art. Frank Auerbach: Drawings of People includes texts by both the editors and the artist himself, and new essays by Kate Aspinall, James Finch, Alex Massouras, David Mellor, and Barnaby Wright. Distributed for the Paul Mellon Centre for Studies in British Art

Caroline of Ansbach (1683-1737), Augusta of Saxe-Gotha (1719-1772), and Charlotte of Mecklenberg-Strelitz (1744-1818) were three German princesses who became Queens Consort-or, in the case of Augusta, Queen in Waiting, Regent, and Princess Dowager-of Great Britain, and were linked by their early years at European princely courts, their curiosity, aspirations, and an investment in Enlightenment thought. This sumptuously illustrated book considers the ways these powerful, intelligent women left enduring marks on British culture through a wide range of activities: the promotion of the court as a dynamic forum of the Hanoverian regime; the enrichment of the royal collection of art; the advancement of science and industry; and the creation of gardens and menageries. Objects included range from spectacular state portraits to pedagogical toys to plant and animal specimens, and reveal how the new and novel intermingled with the traditional. Published in association with the Yale Center for British Art and Historic Royal Palaces Exhibition Schedule: Yale Center for British Art (02/02/17-04/30/17) Kensington Palace (06/22/17-11/12/17)

Exploring the Illusion of Free Will and Moral Responsibility investigates the philosophical and scientific arguments for free will skepticism and their implications. Skepticism about free will and moral responsibility has been on the rise in recent years. In fact, a significant number of philosophers, psychologists, and neuroscientists now either doubt or outright deny the existence of free will and/or moral responsibility-and the list of prominent skeptics appears to grow by the day. Given the profound importance that the concepts of free will and moral responsibility hold in our lives-in understanding ourselves, society, and the law-it is important that we explore what is behind this new wave of skepticism. It is also important that we explore the potential consequences of skepticism for ourselves and society. Edited by Gregg D. Caruso, this collection of new essays brings together an internationally recognized line-up of contributors, most of whom hold skeptical positions of some sort, to display and explore the leading arguments for free will skepticism and to debate their implications.

Exploring the Illusion of Free Will and Moral Responsibility investigates the philosophical and scientific arguments for free will skepticism and their implications. Skepticism about free will and moral responsibility has been on the rise in recent years. In fact, a significant number of philosophers, psychologists, and neuroscientists now either doubt or outright deny the existence of free will and/or moral responsibility-and the list of prominent skeptics appears to grow by the day. Given the profound importance that the concepts of free will and moral responsibility hold in our lives-in understanding ourselves, society, and the law-it is important that we explore what is behind this new wave of skepticism. It is also important that we explore the potential consequences of skepticism for ourselves and society. Edited by Gregg D. Caruso, this collection of new essays brings together an internationally recognized line-up of contributors, most of whom hold skeptical positions of some sort, to display and explore the leading arguments for free will skepticism and to debate their implications.